Sleep Quality Perception in the Chronic Fatigue Syndrome:
Correlations with Sleep Efficiency, Affective Symptoms and Intensity
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Journal: Neuropsychobiology. 2007 Nov 6;56(1):40-46 [Epub ahead of
Authors: Neu D, Mairesse O, Hoffmann G, Dris A, Lambrecht LJ,
Linkowski P, Verbanck P, Le Bon O.
Affiliation: Sleep Laboratory, University Hospital Brugmann,
Université Libre de Bruxelles, Brussels, Belgium.
NLM Citation: PMID: 17986836
Background/Aims: One of the core symptoms of the chronic fatigue
syndrome (CFS) is unrefreshing sleep and a subjective sensation of
poor sleep quality. Whether this perception can be expressed, in a
standardized questionnaire as the Pittsburgh Sleep Quality Index
(PSQI), has to our knowledge never been documented in CFS.
Furthermore, correlations of subjective fatigue, PSQI, affective
symptoms and objective parameters such as sleep efficiency are poorly
described in the literature.
Methods: Using a cross-sectional paradigm, we studied subjective
measures like PSQI, Fatigue Severity Scale scores and intensity of
affective symptoms rated by the Hamilton Depression and Anxiety
scales as well as objective sleep quality parameters measured by
polysomnography of 28 'pure' (no primary sleep and no psychiatric
disorders) CFS patients compared to age- and gender-matched healthy
Results: The PSQI showed significantly poorer subjective sleep
quality in CFS patients than in healthy controls. In contrast,
objective sleep quality parameters, like the Sleep Efficiency Index
(SEI) or the amount of slow-wave sleep did not differ significantly.
Subjective sleep quality showed a correlation trend with severity of
fatigue and was not correlated with the intensity of affective
symptoms in CFS.
Conclusion: Our findings indicate that a sleep quality misperception
exists in CFS or that potential nocturnal neurophysiological
disturbances involved in the nonrecovering sensation in CFS are not
expressed by sleep variables such as the SEI or sleep stage
distributions and proportions.
Copyright (c) 2007 S. Karger AG, Basel.
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