Perception versus polysomnographic assessment of sleep in CFS and
non-fatigued control subjects: results from a population-based study.
Journal: BMC Neurol. 2007 Dec 5;7(1):40 [Epub ahead of print]
Authors: Majer M [1,2], Jones JF , Unger ER , Solomon
Youngblood L , Decker MJ , Gurbaxani B , Heim C , Reeves
 Department of Psychiatry and Behavioral Sciences, Emory
University School of Medicine, Atlanta, USA
 Chronic Viral Diseases Branch, Centers for Disease Control &
Prevention, Atlanta, USA,
 Fusion Sleep, Suwanee, USA
NLM Citation: PMID: 18053240
BACKGROUND: Complaints of unrefreshing sleep are a prominent
component of chronic fatigue syndrome (CFS); yet, polysomnographic
studies have not consistently documented sleep abnormalities in CFS
patients. We conducted this study to determine whether alterations in
objective sleep characteristics are associated with subjective
measures of poor sleep quality in persons with CFS.
METHODS: We examined the relationship between perceived sleep quality
and polysomnographic measures of nighttime and daytime sleep in 35
people with CFS and 40 non-fatigued control subjects, identified from
the general population of Wichita, Kansas and defined by empiric
criteria. Perceived sleep quality and daytime sleepiness were
assessed using clinical sleep questionnaires. Objective sleep
characteristics were assessed by nocturnal polysomnography and
daytime multiple sleep latency testing.
RESULTS: Participants with CFS reported unrefreshing sleep and
problems sleeping during the preceding month significantly more often
than did non-fatigued controls. Participants with CFS also rated
their quality of sleep during the overnight sleep study as
significantly worse than did control subjects. Control subjects
reported significantly longer sleep onset latency than latency to
fall asleep as measured by PSG and MSLT. There were no significant
differences in sleep pathology or architecture between subjects with
CFS and control subjects.
CONCLUSION: People with CFS reported sleep problems significantly
more often than control subjects. Yet, when measured these parameters
and sleep architecture did not differ between the two subject groups.
A unique finding requiring further study is that control, but not CFS
subjects, significantly over reported sleep latency suggesting CFS
subjects may have an increased appreciation of sleep behaviour that
may contribute to their perceived sleep problems.
[Note: This is an Open Access article. The full text is
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